文献类型：期刊文献

英文题名：Therapeutic strategies against bacterial biofilms

作者：Bi, Yufang[1];Xia, Guixue[2];Shi, Chao[2];Wan, Jianglin[2];Liu, Longqiang[2];Chen, Yuan[2];Wu, Yueming[2];Zhang, Wenjing[2];Zhou, Min[2];He, Hongyan[2];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Mat & Dynam Chem, Key Lab Specially Funct Polymer Mat & Related Tec, Sch Mat Sci & Engn,Minist Educ, Shanghai 200237, Peoples R China

年份：2021

卷号：1

期号：2

起止页码：193

外文期刊名：FUNDAMENTAL RESEARCH

收录：WOS:【ESCI(收录号:WOS:000887928800001)】；

基金：This work was supported by the Natural Science Foundation of Shanghai (18ZR1410300), the National Natural Science Foundation of China (No. 21861162010, 21774031, 31800801), Program of Shanghai Academic/Technology Research Leader (20XD1421400), the National Key Research and Development Program of China (2016YFC1100401), Research Program of State Key Laboratory of Bioreactor Engineering, and the Fundamental Research Funds for the Central Universities (No. 22221818014, 50321041917001)

语种：英文

外文关键词：Antimicrobial resistance; Biofilm; Persister cell; Nanomaterials; Drug delivery

摘要：The emergence of multi-drug resistance makes bacterial infection a major threat to public health and economy. The formation of bacterial biofilms is one of the main reasons of bacterial resistance. The complexity of chemical composition and physical structure makes the elimination of mature biofilms a difficult problem. The highly antibiotic resistant property of biofilms urgently calls for potent antimicrobial agents and novel antibiofilm strategies. Researchers have made a lot of efforts in this field. Here we review the current strategies to eliminate mature biofilms and progress in related drug delivery nanosystems, with the aim of inspiring researchers to design new antibiofilm systems.