文献类型：期刊文献

英文题名：Folate-polydiacetylene-liposome for tumor targeted drug delivery and fluorescent tracing

作者：Li, Lielie[1];An, Xueqin[1];Yan, Xiaojuan[1]

机构：[1]E China Univ Sci & Technol, Inst Chem & Mol Engn, Dept Chem, Shanghai 200237, Peoples R China

年份：2015

卷号：134

起止页码：235

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20153001074621);WOS:【SCI-EXPANDED(收录号:WOS:000362142000029)】；

基金：This research was supported by the National Natural Science Foundation of China (nos. 21473055, 21273073 and 21073063), the National High-Tech R&D (863) Program of China (no. 2011AA06A107).

语种：英文

外文关键词：Liposome; Targeted drug delivery; Fluorescent imaging; Folic acid; Polydiacetylene

摘要：A novel folate-polydiacetylene-liposome (FP-PL) with both targeted drug delivery and fluorescence tracing was prepared by thin film rehydration method.The simulated drug delivery was performed in Bcap-37 breast cancer cells and Hs578Bst normal cells in vitro. The internalization and distribution of FP-PLs in the cells were presented by fluorescence cell imaging. The results show that the FP-PLs possess low cytotoxicity, good biocompatibility and better targeting efficiency in comparison to polydiacetylene-liposomes (P-P1s). (C) 2015 Elsevier B.V. All rights reserved.