文献类型：期刊文献

英文题名：Hydrogen-bond-mediated asymmetric catalysis

作者：Yu, Xinhong[2];Wang, Wei[1,2]

机构：[1]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2008

卷号：3

期号：3

起止页码：516

外文期刊名：CHEMISTRY-AN ASIAN JOURNAL

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000254358800003)】；

语种：英文

外文关键词：asymmetric catalysis; diols; hydrogen bonds; phosphoric acids; ureas

摘要：The utilization of hydrogen bonding as an activation force has become a powerful tool in asymmetric organocatalysis. Significant advances have been made in the recent past in this emerging field. Due to space constraints, this Focus Review summarizes only the key aspects with an emphasis on catalysis based on chiral ureas and thioureas, diols, and phosphoric acids. The examples provided neatly demonstrate that chiral ureas and thioureas, diols, and phosphoric acids display effective and unique activation modes of catalysis for a broad spectrum of asymmetric organic transformations, including single-step and multiple-step cascade reactions. These functionalities, which have the ability to afford efficient H-bond activation of electrophiles including C=O, C=N, aziridines, and epoxides, have established their status as "privileged" functional groups in the design of organ ocatalysts.