文献类型：期刊文献

英文题名：Sequential catalytic nanomedicine augments synergistic chemodrug and chemodynamic cancer therapy

作者：Liang, Ruijie[1];Chen, Yu[2];Huo, Minfeng[2];Zhang, Jun[3];Li, Yongsheng[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Lab Low Dimens Mat Chem,Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China;[3]Fudan Univ, Huashan Hosp, Dept Radiol, Shanghai 200040, Peoples R China

年份：2019

卷号：4

期号：4

起止页码：890

外文期刊名：NANOSCALE HORIZONS

收录：;EI(收录号：20192607113995);WOS:【SCI-EXPANDED(收录号:WOS:000474586600006)】；

基金：We greatly acknowledge the financial support from the National Key Research and Development Program of China (Grant No. 2016YFA0203700), the National Nature Science Foundation of China (Grant No. 51672303, 51722211, 51461165202 and 51472085), the Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001), the National Natural Science Foundation of China for Innovative Research Groups (Grant No. 51621002) and the Fundamental Research Funds for Central Universities (Grant No. 222201718002).

语种：英文

外文关键词：Glucose sensors - Cancer cells - Glucose oxidase - Oxygen - Diseases - Magnetite - Medical nanotechnology - Drug delivery - Glucose - Nanocatalysts - Oxidation

摘要：The tumor microenvironment (TME) provides intriguing features/indications for rational design of diverse therapeutic protocols with high tumor specificity and therapeutic efficacy. In this work, we report the introduction of the sequential catalytic concept into theranostic nanomedicine for cancer-specific therapy, which has been achieved by the construction of glucose oxidase (GOD) and Mitomycin C (MMC) co-loaded superparamagnetic iron oxide nanoparticles (designated as SMG nanocatalysts). Based on the large amounts of glucose in tumors, the GOD component in SMG catalyzes glucose to convert into hydrogen peroxide (H2O2) and gluconic acid with the simultaneous consumption of oxygen. The post-produced H2O2 is further catalyzed by iron oxide in SMG to produce large amounts of highly toxic hydroxyl radicals for cancer therapy, and the generated gluconic acid enhances such a Fenton-based catalytic reaction. On the other hand, the loaded MMC drug is activated because of the consumption of oxygen and enhanced hypoxia in tumors, causing high chemotherapeutic efficacy. Based on the high synergistic chemodrug and chemodynamic therapeutic efficacy in combating cancer, cancer cells are efficiently killed and tumor growth is thus significantly suppressed. This work paves a new way for cancer therapy by taking into account the full features and advantages of the TME and the physiochemical properties of the chosen nanocatalysts, which also links nanocatalytic science and nanomedicine for proposing new efficient tumor-therapeutic modalities.