文献类型：期刊文献

英文题名：Recent advances in the biosynthesis and production optimization of gentamicin: A critical review

作者：Xu, Feng[1];Hu, Kaihao[1];Mohsin, Ali[1];Wu, Jie[1];Su, Lihuan[1];Wang, Yuan[1];Ben, Rong[1];Gao, Hao[1];Tian, Xiwei[1];Chu, Ju[1]

机构：[1]East China Univ Sci & Technol, Qingdao Innovat Inst, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2025

卷号：10

期号：1

起止页码：247

外文期刊名：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001378931500001)】；

基金：This work was financially supported by the National Key Research and Development Program of China (2022YFC2105403) , the Taishan Scholars Program, the Shanghai Pilot Program for Basic Research (22TQ1400100-14) , the Natural Science Foundation of Shanghai (23ZR1416500) , the Frontiers Science Center for Materiobiology and Dynamic Chemistry (JKVJ1231036) . Thanks for the financial support from the Arawana Charity Foundation.

语种：英文

外文关键词：Micromonospora; Gentamicin biosynthesis; Fermentation process optimization; Molecular regulation; Aminoglycosides

摘要：Gentamicin, an aminoglycoside antibiotic, is generated by a few species within the genus Micromonospora and has garnered significant attention due to its broad-spectrum efficacy in combating numerous infectious diseases. Comprising a complex array of closely related aminoglycoside compounds, the gentamicin B and C complexes emerge as particularly pertinent in clinical contexts. This review outlines the latest advancements in the biosynthesis and production of gentamicin, commencing with a comprehensive overview of its biosynthetic pathway. Subsequently, the article encapsulates a spectrum of strategies currently deployed to augment gentamicin yields. These strategies include mutation screening, molecular biological techniques, and optimization of the fermentation process. Moreover, numerous methods have been documented for detecting gentamicin across a range of matrices, underscoring the significance of precise quantitative analysis. Finally, the review furnishes an exhaustive market analysis and future outlook, elucidating prevailing trends and challenges within the gentamicin industry. Overall, this article serves as a pivotal resource for researchers and professionals engaged in gentamicin research, furnishing a meticulous introduction to efficient synthesis technologies and diverse applications, alongside presenting innovative concepts and methodologies aimed at increasing gentamicin production.