文献类型：期刊文献

英文题名：Electrochemical sensor based on molecularly imprinted polymer for sensitive and selective determination of metronidazole via two different approaches

作者：Liu, Jie[1];Tang, Hui[1];Zhang, Bo[1];Deng, Xiling[1];Zhao, Feilang[3];Zuo, Peng[4];Ye, Bang-Ce[2,4];Li, Yingchun[1,2,3]

机构：[1]Shihezi Univ, Sch Pharm, Minist Educ, Key Lab Xinjiang Phytomed Resources, Shihezi 832000, Peoples R China;[2]Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China;[3]Jiangsu Devote Instrumental Sci & Technol Co Ltd, Huaian 223001, Jiangsu, Peoples R China;[4]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2016

卷号：408

期号：16

起止页码：4287

外文期刊名：ANALYTICAL AND BIOANALYTICAL CHEMISTRY

收录：;EI(收录号：20161702301104);WOS:【SCI-EXPANDED(收录号:WOS:000376456300009)】；

基金：This project was financially supported by the Major Program for Science and Technology Development of Shihezi University (gxjs2014-zdgg04), National Natural Science Foundation of China (81260487, 81460543, 21575089), the Scientific Research Foundation for the Returned Overseas Chinese Scholars from Ministry of Human Resources and Social Security of China (RSLX201301), the Pairing Program of Shihezi University with Eminent Scholar in Elite University (SDJDZ201502, SDJDZ201503), and Open Funding Project of the State Key Laboratory of Bioreactor Engineering.

语种：英文

外文关键词：Electrochemical sensor; Electro-catalysis; Gate effect; Metronidazole; Molecularly imprinted polymer

摘要：A molecularly imprinted polymer decorated glassy carbon electrode (MIP/GCE) is facilely developed into an electrochemical sensing platform for detection of metronidazole (MNZ). MIP preparation was carried out via in situ electropolymerization and o-phenylenediamine was selected as the optimal functional monomer. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were employed to characterize and assess the performance of the so-obtained sensor. In particular, two assay methods, which are based on different principles, were involved in the detection procedure. One is based on MIP/catalysis (Method D dagger) and the other is MIP/gate effect (Method II). Comparison of these two methods was made in the aspects including detection range, sensitivity, accuracy, selectivity, repeatability, and long-term stability. It is found that Method D dagger affords a lower detection limit of 3.33 x 10(-10) M (S/N = 3) while the detection limit of Method II is 6.67 x 10(-10) M (S/N = 3). The linear range of Method D dagger and II is 1.0 x 10(-9) to 1.0 x 10(-8) M and 2.0 x 10(-9) to 1.0 x 10(-7) M, respectively. The MIP/GCE exhibits good recognition ability towards the template molecule-MNZ in the presence of the analogues of MNZ and other interferents, which can be ascribed to the successful imprinting effect during MIP membrane preparation.