文献类型：期刊文献

英文题名：Injectable double-crosslinked bone cement with enhanced bone adhesion and improved osteoporotic pathophysiological microenvironment for osteoregeneration in osteoporosis

作者：Zhao, Lingfei[1,2,3];Liu, Chenyu[1,2,3];Chen, Xing[1,2,3];He, Zirui[1,2,3];Zhang, Shuiquan[1,2,3];Zhang, Anan[1,2,3];Tang, Shuaimin[1,2,3];Wu, Zihan[5];Liu, Changsheng[1,2,3,4];Yuan, Yuan[1,2,3,4]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China;[5]Shanghai Rebone Biomat Co Ltd, Shanghai 201707, Peoples R China

年份：2025

卷号：43

起止页码：441

外文期刊名：BIOACTIVE MATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001332546100001)】；

基金：The authors wish to express their gratitude to the financial support from National Key Research and Development Program of China (No.2022YFB3804300) and (No.2022YFC2405702) , Program of Shanghai Academic/Technology Research Leader (22XD1433900) , Frontiers Science Center for Materiobiology and Dynamic Chemistry (No.JKVD1211002) , and Chinese Academy of Sciences-WEGO Research and Development Program ( [2023] 005) , and the National Natural Science Foundation of China (No.32271401)

语种：英文

外文关键词：Injectable bone cement; Double crosslinked network; Bone adhesion; Bone homeostasis; Osteoclastogenesis; Osteoporotic bone regeneration

摘要：The osteoporotic bone defect caused by excessive activity of osteoclasts has posed a challenge for public healthcare. However, most existing bioinert bone cement fails to effectively regulate the pathological bone microenvironment and reconstruct bone homeostasis in the presence of osteoclast overactivity and osteoblast suppression. Herein, inspired by natural bone tissue, an in-situ modulation system for osteoporotic bone regeneration is developed by fabricating an injectable double-crosslinked PEGylated poly(glycerol sebacate) (PEGS)/calcium phosphate cement (CPC) loaded with sodium alendronate (ALN) (PEGS/CPC@ALN) adhesive bone cement. By incorporating ALN, the organic-inorganic interconnection within PEGS/CPC@ALN results in a 100 % increase in compression modulus and energy dissipation efficiency. Additionally, PEGS/CPC@ALN effectively adheres to the bone by bonding with amine and calcium ions present on the bone surface. Moreover, this in-situ regulation system comprehensively mitigates excessive bone resorption through the buffering effect of CPC to improve the acidic microenvironment of osteoporotic bone and the release of ALN to inhibit hyperactive osteoclasts, and facilitates stem cell proliferation and differentiation into osteoblasts through calcium ion release. Overall, the PEGS/CPC@ALN effectively regulates the pathological microenvironment of osteoporosis while promoting bone regeneration through synergistic effects of drugs and materials, thereby improving bone homeostasis and enabling minimally invasive treatment for osteoporotic defects.