文献类型：期刊文献

英文题名：Recent advances of carbon dots in imaging-guided theranostics

作者：Chen, Bin Bin[2,3];Liu, Meng Li[2];Huang, Cheng Zhi[1]

机构：[1]Southwest Univ, Coll Pharmaceut Sci, Chongqing Sci & Technol Bur,Key Lab Luminescence, Key Lab Luminescence Anal & Mol Sensing,Minist Ed, Chongqing 400715, Peoples R China;[2]Southwest Univ, Coll Chem & Chem Engn, Chongqing 400715, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2021

卷号：134

外文期刊名：TRAC-TRENDS IN ANALYTICAL CHEMISTRY

收录：;EI(收录号：20204809539526);WOS:【SCI-EXPANDED(收录号:WOS:000611900400003)】；

基金：We are grateful for the financial support from the National Natural Science Foundation of China (NSFC, Grant No. 21976144).

语种：英文

外文关键词：Carbon dots; Imaging guidance; Cancer therapy; Drug delivery system; Photothermal therapy; Photodynamic therapy

摘要：Cancer threatens the life and health of human beings, while the effective treatment of cancer is a major challenge. The design of fluorescent probe provides the strategy for developing effective therapeutic nanomaterials that can detect and identify cancer cells as well as achieve targeted and image-guided cancer therapy. Among the fluorescent nanomaterials studied, carbon dots (CDs) have attracted increasing attention owing to their most significant advantages in terms of diverse imaging features, high drug loading as well as low toxicity, and thus they have emerged as one of the most appealing candidates in the field of imaging-guided theranostics. In this review, we firstly overview the imaging analysis of cancer cells, including single-modal imaging and multi-modal imaging. After the introduction of diverse imaging features, we focus on the design of imaging-assisted drug delivery system. Finally, the current development of CDs in imaging-guided photothermal therapy (PTT) and photodynamic therapy (PDT) are further described. (C) 2020 Elsevier B.V. All rights reserved.