文献类型：期刊文献

英文题名：β-Tricalcium phosphate/poly(glycerol sebacate) scaffolds with robust mechanical property for bone tissue engineering

作者：Yang, Kai[1,3];Zhang, Jing[2,3];Ma, Xiaoyu[2,3];Ma, Yifan[2,3];Kan, Chao[2,3];Ma, Haiyan[3];Li, Yulin[3];Yuan, Yuan[1,3];Liu, Changsheng[1,2,3]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, PR, Peoples R China;[2]E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, PR, Peoples R China;[3]E China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China

年份：2015

卷号：56

起止页码：37

外文期刊名：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS

收录：;EI(收录号：20152500947104);WOS:【SCI-EXPANDED(收录号:WOS:000359873900005)】；

基金：The authors wish to express their gratitude for financial support from the National Basic Research Program of China (973 Program, No. 2012CB933600), National Natural Science Foundation of China (No 31330028, No.31470924, No.31400817), the 111 Project (B14018), and Shanghai Municipal Science Foundation (15ZR1408500). This study was also supported by the Program for New Century Excellent Talents in University (No. NCET-11-0640) and the National Special Fund for State Key Laboratory of Bioreactor Engineering (No.2060204).

语种：英文

外文关键词：beta-Tricalcium phosphate; Poly(glycerol sebacate); Porous scaffold; Robust mechanical property; Bone regeneration

摘要：Despite good biocompatibility and osteoconductivity, porous beta-TCP scaffolds still lack the structural stability and mechanical robustness, which greatly limit their application in the field of bone regeneration. The hybridization of beta-TCP with conventional synthetic biodegradable PLA and PCL only produced a limited toughening effect due to the plasticity of the polymers in nature. In this study, a beta-TCP/poly(glycerol sebacate) scaffold (beta-TCP/PGS) with well interconnected porous structure and robust mechanical property was prepared. Porous beta-TCP scaffold was first prepared with polyurethane sponge as template and then impregnated into PGS pre-polymer solution with moderate viscosity, followed by in situ heat crosslinking and freezing-drying process. The results indicated that the freezing-drying under vacuum process could further facilitate crosslinking of PGS and formation of Ca2+-COO- ionic complexing and thus synergistically improved the mechanical strength of the beta-TCP/PGS with in situ heat crosslinking. Particularly, the beta-TCP/PGS with 15% PGS content after heat crosslinking at 130 degrees C and freezing-drying at -50 degrees C under vacuum exhibited an elongation at break of 375 +/- 25% and a compressive strength of 1.73 MPa, 3.7-fold and 200-fold enhancement compared to the beta-TCP, respectively. After the abrupt drop of compressive load, the beta-TCP/PGS scaffolds exhibited a full recovery of their original shape. More importantly, the PGS polymer in the beta-TCP/PGS scaffolds could direct the biomineralization of Ca/P from particulate shape into a nanofiber-interweaved structure. Furthermore, the beta-TCP/PGS scaffolds allowed for cell penetration and proliferation, indicating a good cytobiocompatibility. It is believed that beta-TCP/PGS scaffolds have great potential application in rigid tissue regeneration. (C) 2015 Elsevier B.V. All rights reserved.