文献类型：期刊文献

英文题名：One-Pot Addition-Intramolecular N-Cyclization of Carbamates Mediated by Alkali Metallic Reagents as an Approach to 4-(Fluoroalkyl)oxazolidin-2-ones

作者：Yang, Xue-Yan[1,2];Fang, Xiang[1,2];Ju, Zheng-Hua[1,2];Hu, Yun-Li[1,2];Wu, Fan-Hong[1,2,3]

机构：[1]E China Univ Sci & Technol, Adv Mat Lab, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 200235, Peoples R China

年份：2011

期号：22

起止页码：3627

外文期刊名：SYNTHESIS-STUTTGART

收录：;EI(收录号：20114614511415);WOS:【SCI-EXPANDED(收录号:WOS:000298156600007)】；

基金：This work was supported by the National Natural Science Foundation of China (No. 20972050, No. 21172148) and the Science and Technology Commission of Shanghai Municipality (No. 10540501300).

语种：英文

外文关键词：allyl carbamates; 4-(fluoroalkyl)oxazolidin-2-ones; addition-intramolecular N-cyclization; alkali metallic reagents

摘要：A mild and straightforward strategy for the synthesis of 4-(fluoroalkyl)oxazolidin-2-ones via one-pot addition-intramolecular N-cyclization of allyl carbamates with fluoroalkyl iodides is presented. The reaction proceeded in moderate to good yield through regiocontrol and an increase in the reactivity of the ambident nucleophiles by the use of alkali metallic reagents.