文献类型：期刊文献

英文题名：Quinine-thiourea catalyzed enantioselective hydrophosphonylation of trifluoromethyl 2(1H)-quinazolinones

作者：Xie, Hexin[1,2];Song, Aiguo[1];Zhang, Xinshuai[1];Chen, Xiaobei[1];Li, Hao[2];Sheng, Chunquan[3];Wang, Wei[1,2]

机构：[1]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[3]Second Mil Med Univ, Sch Pharm, Dept Med Chem, Shanghai 200433, Peoples R China

年份：2013

卷号：49

期号：9

起止页码：928

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000312944700025)，CCR-EXPANDED(收录号:WOS:000312944700025)】；

基金：Financial support for this research is provided by the National Science foundation (CHE-1057569), the China 111 Project (Grant B07023) and East China University of Science & Technology. We also acknowledge the NSF for providing support of NMR facilities at UNM (NSF grants 0840523 and 0946690).

语种：英文

摘要：An organocatalytic enantioselective addition reaction of cyclic ketoimines with phosphites has been developed for the first time. The process, catalyzed by Soos' quinine thiourea, affords synthetically and medicinally interesting enantioenriched trifluoromethyl dihydroquinazolinones in high yields and with high enantioselectivities.