文献类型：期刊文献

英文题名：6-O-Angeloylenolin induces apoptosis through a mitochondrial/caspase and NF-κB pathway in human leukemia HL60 cells

作者：Li ChangLong[1,2];Wu HeZhen[3];Huang YongPing[1,2];Yang YanFang[3];Liu YanWen[3];Liu JianWen[1,2]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[3]Hubei Coll Tradit Chinese Med, Key Lab Resources & Chem Chinese Med, Wuhan 430061, Hubei, Peoples R China

年份：2008

卷号：62

期号：6

起止页码：401

外文期刊名：BIOMEDICINE & PHARMACOTHERAPY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000258206900010)】；

语种：英文

外文关键词：6-O-Angeloylenolin; apoptosis; lung tumor cells

摘要：6-0-Angeloylenolin, a sesquiterpene lactone from Centipeda minima, has been known to have anti-tumor activity against human colorectum, liver, stomach, lung, and skin tumor cells. However, its molecular mechanism is still obscure and insufficient in in vivo tests. In this study, we demonstrated that 6-O-angeloylenolin could induce apoptosis in human leukemia HL60 cells through stimulating the generation of reactive oxygen species, decreasing mitochondrial trans-membrane potential (Delta Psi m) and activating caspase-3/7. We also found that 6-O-angeloylenolin could inhibit nuclear translocation of NF-kappa B and modulate the expression of Bcl-2 gene family. These results indicated that 6-O-angeloylenolin induces apoptosis by inhibition of NF-kappa B activation, modulation of Bcl-2 gene family expression and destruction of mitochondrial function. Furthermore, we confirmed that 6-O-angeloylenolin could obviously inhibit the solid cancer growth in Lewis lung cancer xenograft models. (c) 2007 Elsevier Masson SAS. All rights reserved.