文献类型：期刊文献

英文题名：Effective guest uptake and release using an azobenzene-embedded molecular cage

作者：Chen, Dizhi[1];Chen, Xujin[1];Guo, Qichao[1];Wang, Jiaqi[1];Wang, Qiaochun[1];Zou, Lei[1]

机构：[1]East China Univ Sci & Technol, Inst Fine Chem,Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr,Joint, Frontiers Sci Ctr Materiobiol & Dynam Chem,Key Lab, Shanghai 200237, Peoples R China

年份：2024

卷号：222

外文期刊名：DYES AND PIGMENTS

收录：;EI(收录号：20234915154900);WOS:【SCI-EXPANDED(收录号:WOS:001128100100001)】；

基金：This work was financially supported by the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Azobenzene; Molecular cages; Controlled release; Host-guest chemistry; Photoisomerization

摘要：Designing cages with switchable cavities towards guests is the key for effective drug loading and controlled release. For this purpose, a new asymmetrical molecular cage containing two aza-vertices and three linkers-one azobenzene group and two diphenyl ether units-was synthesized. After complexing with two copper ions onto the vertices, the formed di-metallic cage shows a strong binding affinity (Ka = 1.58 x 107 M-1) towards a rhodamine dicarboxylate anion and can capture 79% of the guest in CH3CN/H2O solution even at extremely low concentrations of both 1.0 x 10-6 M. Furthermore, owing to high E -> Z photoisomerization efficiency of the embedded azobenzene unit, 84% of the loaded rhodamine guest would be released from the cage cavity by UV light irradiation.