文献类型：期刊文献

英文题名：Improvement of surface hydrophilicity, water uptake, biodegradability, and cytocompatibility through the incorporation of chitosan oligosaccharide into poly(l-lactide)

作者：Wang, Xuehong[1];Wei, Jie[1];Chen, Jianding[1];Tang, Songchao[1]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China

年份：2018

卷号：135

期号：4

外文期刊名：JOURNAL OF APPLIED POLYMER SCIENCE

收录：;EI(收录号：20173704154956);WOS:【SCI-EXPANDED(收录号:WOS:000412933900007)】；

基金：This study is financially supported by the National Natural Science Foundation of China (Grant No. 31271031, 51173041), the International Cooperation Project of the Ministry of Science and Technology of China (2013DFB50280), the National High Technology Research & Development Program of China (863 Program) (no. 2014AA021202), the Major International Joint Research Project between China and Korea (81461148033, 31311140253), and Special Program of Strategic Emerging Industries Development of Shenzhen (CXZZ2012070355537097).

语种：英文

外文关键词：biodegradable; biomaterials; biomedical applications; degradation; polysaccharides

摘要：Poly(l-lactide) (PLLA)-based biocomposites incorporated with different amounts of chitosan oligosaccharide (COS) were developed through solvent-casting method. Then, the physical-chemical properties, surface morphology, hydrophilicity, water uptake, biodegradability, and biocompatibility of the COS/PLLA composites were investigated. Fourier transform infrared and X-ray diffraction results showed that strong hydrogen-bonding interactions were presented between the COS and PLLA components. Scanning electron microscope and atomic force microscope images revealed that COS physically attached on the PLLA surface enhanced the formation of the surface seepage network, which led to the improvement of the surface biological features. A gradual rise in the level of hydrophilicity, water uptake, and degradation rate in phosphate buffered saline solution were found on increasing COS content in the COS/PLLA composites, which may provide effective support for cell adhesion and proliferation. Further, the results of cell experiments also suggested that the COS/PLLA composites had better cytocompatibility compared with PLLA. Thus, the COS/PLLA composites may have the great potential to be used for soft and bone tissue repair. (c) 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45724.