文献类型：期刊文献

英文题名：Toward Understanding the Effect of Solvent Evaporation on the Morphology of PLGA Microspheres by Double Emulsion Method

作者：Si, Wei[1];Yang, Qingqing[2];Zong, Yuan[1];Ren, Guobin[2,3];Zhao, Ling[1];Hong, Minghuang[2];Xin, Zhong[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Minist Educ,Lab Pharmaceut Crystal Engn & Technol, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2021

卷号：60

期号：25

起止页码：9196

外文期刊名：INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

收录：;EI(收录号：20212910647156);WOS:【SCI-EXPANDED(收录号:WOS:000670420500024)】；

语种：英文

外文关键词：Emulsification - Evaporation - Morphology - Microspheres - Diffusion

摘要：During the fabrication of poly(lactide-co-glycolic acid) (PLGA) microspheres by the water/oil/water (W-1/O/W-2) emulsion solvent evaporation method, water permeation coupled with dichloromethane (DCM) volatilization represents a critical process affecting the microsphere morphology. In this work, the mechanism of pore formation in PLGA through water permeation has been verified. By molecular simulations, the diffusion coefficients of water with different DCM contents were determined. The results showed that the diffusion coefficient decreased rapidly from 53.33 X 10(-6) to 6.73 X 10(-6) cm(2)/s after decreasing the DCM mass fraction from 94 to 63%. Furthermore, the higher stirring speed and lower volume of the external aqueous phase promoted the DCM volatilization. Two different mass transfer stages were identified for water permeation, and the first stage could be considered the main mass transfer window because of its high diffusion coefficient. The morphology of PLGA microspheres confirmed the existence of a relationship between water permeation and DCM volatilization.