文献类型：期刊文献

英文题名：Construction of N-Boc monofluoromethyl aryl sulfones via Mannich reaction of α-amido sulfones with trifluoromethyl α-fluorinated arylsulfonyl gem-diols

作者：Wang, Wang[1];Fang, Xiang[1];Yang, Xueyan[1];Wu, Fanhong[2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Haiquan Rd, Shanghai 201418, Peoples R China

年份：2020

卷号：235

外文期刊名：JOURNAL OF FLUORINE CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000539436700005)】；

基金：The authors thank the National Natural Science Foundation of China (No. 21672151) for financial support.

语种：英文

外文关键词：Mannich reaction; Nucleophilic monofluoromethylation; Trifluoromethyl alpha-fluorinated arylsulfonyl gem-diols; Detrifluoroacetylation

摘要：A mild and efficient nucleophilic monofluoromethylation of alpha-amido sulfones with trifluoromethyl alpha-fluorinated arylsulfonyl gem-diols as new building blocks has been developed, which affords N-Boc monofluoromethyl aryl sulfones in good yields with appropriate 5:1 diastereomeric ratio.