文献类型：期刊文献

英文题名：Blended films containing polybutyrolactam and chitosan for potential wound dressing applications

作者：Wu, De[1];Wei, Wu[2];Li, Hong[3];Wang, Xuehong[1];Wang, Tinglan[1];Tang, Songchao[1];Li, Quan[4];Yao, Yuan[1];Pan, Yongkang[1];Wei, Jie[1]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]Nanjing Tech Univ, Coll Mat Sci & Engn, Nanjing 210009, Jiangsu, Peoples R China;[3]Sichuan Univ, Coll Phys Sci & Technol, Chengdu 610041, Sichuan, Peoples R China;[4]Second Mil Med Univ, Changhai Hosp, Dept Orthopaed Trauma, Shanghai 200433, Peoples R China

年份：2018

卷号：135

期号：28

外文期刊名：JOURNAL OF APPLIED POLYMER SCIENCE

收录：;EI(收录号：20181404979046);WOS:【SCI-EXPANDED(收录号:WOS:000430391200024)】；

基金：The grants were from the National Natural Science Foundation of China (51772194, 81771990, and 51502340).

语种：英文

外文关键词：applications; biodegradable; biomaterials; films

摘要：In this study, polybutyrolactam (PBA) was synthesized, and the PBA/chitosan (CS) blended films were fabricated for wound dressings. The results showed that the surface roughness of the blended films decreased with the increasing ratios of CS. In addition, the tensile strength of the film with 50 wt % CS (NC50) was about 33.6 MPa and the highest compared with other films. The hydrophilicity of the blended films gradually decreased while the water vapor transmission rates (WVTRs) increased with the increase of CS content. Moreover, the blended films could be biodegradable in phosphate buffer saline. Both PBA and blended films were non-toxic and good for L929 cells growth, showing good cytocompatibility. Furthermore, the NC50 was found to promote the cell proliferation better than other groups. It can be suggested that the NC50 combined the advantages of both PBA and CS well. Therefore, the NC50 with good cytocompatibility, mechanical properties, and WVTRs might be suitable for wound dressingapplications. (C) 2018 Wiley Periodicals, Inc.