文献类型：期刊文献

英文题名：Facile Preparation of Tilmicosin-Loaded Polymeric Nanoparticle with Controlled Properties and Functions

作者：Yu, Jie[1];Wang, Mingwei[1];Ahmed, Rizwan[1];Zhao, Hongyang[1];Stuart, Martien A. Cohen[1];Wang, Junyou[1]

机构：[1]East China Univ Sci & Technol, Sch Chem Engn, Shanghai Key Lab Multiphase Mat Chem Engn, Shanghai 200237, Peoples R China

年份：2020

卷号：5

期号：50

起止页码：32366

外文期刊名：ACS OMEGA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000603283500023)】；

基金：This work was supported by the "1000 Foreign Experts Program" (WQ20163100341), the National Natural Science Foundation of China (NSFC) for Young Scholars (21706074), and the Fundamental Research Funds for the Central Universities (222201814007).

语种：英文

摘要：As one of the effective broad-spectrum antimicrobial and anti-inflammatory drugs, tilmicosin (TIM) is applied extensively in a wide range of veterinary treatments. However, the low bioavailability typically leads to overuse of TIM in practical applications, which can cause residual accumulation in the environment and contamination of foodstuffs. Here, we report a precipitation method that allows us to prepare TIM-loaded poly(methyl methacrylate-co-methacrylic acid) (P(MMA-co-MAA)) nanoparticles. Specifically, TIM and biocompatible P-(MMA-co-MAA) are dissolved in methanol and then water is introduced as an antisolvent, which triggers the co-precipitation and leads to well-controlled nanoparticles. Depending on the drug/polymer mass ratio and the total concentration of drug and polymer, the formed nanoparticles display a tunable radius from 27 to 80 nm with a narrow size distribution, a high drug loading content, and a controlled release of TIM. The encapsulation does not interrupt the antibacterial function of TIM while reducing its cytotoxicity enormously. Moreover, the formed nanoparticles could be dried to powder through freeze-drying, and the redispersion of the particles hardly disturbs the particle size, size distribution, and drug loading content. Our study developed a facile and robust precipitation method for the controlled construction of TIM-loaded polymeric nanoparticles with tunable properties and functions, as well as improved biocompatibility, which shall improve the bioavailability of TIM and enhance the practical applications.