文献类型：期刊文献

英文题名：Engineering near-infrared laser-activated gold nanorod vesicles with upper critical solution temperature for photothermal therapy and chemotherapy

作者：Xing, Wenqian[1,2];Tang, Yao[1];Ji, Yuejia[1];Cheng, Di[1];Wang, Bin[1];Fu, Yun[1,2];Xu, Yufang[1];Qian, Xuhong[1];Zhu, Weiping[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2023

卷号：640

起止页码：41

外文期刊名：JOURNAL OF COLLOID AND INTERFACE SCIENCE

收录：;EI(收录号：20230913633044);WOS:【SCI-EXPANDED(收录号:WOS:000946508700001)】；

基金：This work was supported by National Natural Science Foundation of China (Grants 21878088, 21476077) , Key projects of Shanghai Science and Technology Commission (18DZ1112703) , Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission, grant 2021 Sci & Tech 03-2) and the Research Funds of Happiness Flower ECNU (2020JK2103) .

语种：英文

外文关键词：Gold nanorod vesicle; Upper critical solution temperature (UCST) polymer; Chemotherapy; Photothermal therapy; Controlled-release

摘要：Multimodal synergistic therapy based on nanomedicine drug delivery systems can achieve accurate can-cer treatment. The anisotropy of gold nanorods (AuNRs) allows the adjustment of the longitudinal local-ized surface plasmon resonance absorption to the near-infrared band, which shows potential application in the field of photothermal therapy of cancer. Here, we report a new type of thermal-sensitive gold nanorod drug-loaded vesicles (UGRV-DOX) via the self-assembly of AuNRs modified with the amphiphilic polymer (PEG45-b-PS150) and upper critical solution temperature (UCST) polymer (P(AAm-co-AN)). The hollow structure of the vesicle can increase the drug loading capacity, and the polymers on its surface are intertwined to reduce drug leakage. As-prepared UGRV-DOX vesicles exhibits excellent photothermal conversion efficiency and can achieve light-controlled drug release. In vivo anti-tumor experiments showed that UGRV-DOX could ablate HepG2 transplanted tumors significantly under 808 nm laser irra-diation, and the inhibition rate was as high as 99.3 %. These tumor-specific nanovesicles prefigure great potentials for high-precision cancer treatment. (c) 2023 Elsevier Inc. All rights reserved.