文献类型：期刊文献

英文题名：Adaptable to Mechanically Stable Hydrogels Based on the Dynamic Covalent Cross-Linking of Thiol-Aldehyde Addition

作者：Hua, Yujie[1];Gan, Yibo[2,3];Zhang, Yiqing[1];Ouyang, Bin[2];Tu, Bing[2];Zhang, Chengmin[2];Zhong, Xuepeng[1];Bao, Chunyan[1];Yang, Yi[1];Lin, Qiuning[1];Zhou, Qiang[2];Zhu, Linyong[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Optogenet & Synthet Biol Interdisciplinary Res Ct, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Army Med Univ, Mil Med Univ 3, Natl & Reg United Engn Lab Tissue Engn, Southwest Hosp,Dept Orthoped, 29 Gaotanyan St, Chongqing 400038, Peoples R China;[3]Army Med Univ, Mil Med Univ 3, State Key Lab Trauma Burns & Combined Injury, Inst Rocket Force Med, 29 Gaotanyan St, Chongqing 400038, Peoples R China

年份：2019

卷号：8

期号：3

起止页码：310

外文期刊名：ACS MACRO LETTERS

收录：;EI(收录号：20191106641645);WOS:【SCI-EXPANDED(收录号:WOS:000462098200016)】；

基金：This work was financially supported by the National Nature Science Foundation of China (21774030, 21425311, and 81772378), Key Project of Military Logistics (BWS13C014-1), and Key Project of Military Medical Technology Innovation Program (SWH2016JSZD-01 and SWH2017JCZD-02).

语种：英文

外文关键词：Crosslinking - Addition reactions - pH - Aldehydes - Mechanical stability - Scaffolds

摘要：We exploit the thiol-aldehyde addition (TAA) reaction to build a dynamic covalent cross-linking (DCC) hydrogel in the physiological-pH environment. Due to the rapid and reversible TAA reaction, the resulting hydrogels are readily adapted for convenient manipulation, for example, free molding, easy injection, and self-healing. Meanwhile, the labile hemithioacetal bonds within the DCC hydrogel can convert to thermodynamically stable bonds via spontaneous thiol transfer reactions, thereby realizing poststabilization as needed. The successful application as a long-term scaffold for repair of barely self-healed bone defect indicated the hydrogels with both adaptability and mechanical stability based on thiol-aldehyde addition reaction is significant for biomedical areas.