文献类型：期刊文献

英文题名：Formation of enzymatic/redox-switching nanogates on mesoporous silica nanoparticles for anticancer drug delivery

作者：Luo, Wei[1,2];Xu, Xin[1,2];Zhou, Bingjie[1,2];He, Peixin[3];Li, Yulin[1,2];Liu, Changsheng[1,2]

机构：[1]East China Univ Sci & Technol, Minist Educ, State Key Lab Bioreactor Engn, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[3]Hubei Univ, Coll Chem & Chem Engn, Key Lab Green Preparat & Applicat Funct Mat, Minist Of Educ, Wuhan 430062, Peoples R China

年份：2019

卷号：100

起止页码：855

外文期刊名：MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS

收录：;EI(收录号：20191306690852);WOS:【SCI-EXPANDED(收录号:WOS:000466059700082)】；

基金：This research was supported by the National Key Research and Development Program of China (2017YFB0309300), National Natural Science Foundation of China (81772317), Shanghai International Cooperation Program (15520721200) and Development Fund for Shanghai Talents (201519). We also acknowledged the financial support from Fundamental Research Funds for the Central Universities (WD1714002, WD1717015).

语种：英文

外文关键词：Mesoporous nanoparticles; Gelatin; MMP 2 cleavable; Nanogate; Anticancer drug delivery

摘要：In this study, we demonstrate a simple approach to developing mesoporous nanohybrids via a process of preloading of an anticancer drug (doxorubicin, DOX) into mesoporous silica nanoparticles (MSN), followed by assembly with a kind of naturally-derived polymer (gelatin, cleavable by matrix metalloproteinase 2 overexpressed by tumor). The gelatin shell is then in situ crosslinked by degradable N,N'-bis(acryloyl)cystamine (BAC) to form enzymatic and redox switchable nanogates on the mesoporous nanoparticles. The nanohybrids displayed pH/redox/enzymatic sensitivity in DOX release under conditions mimicking tumor microenvironments. The nanocarriers can be effectively taken up by A549 cells (a carcinomic human alveolar basal epithelial cell line), resulting in a high DOX intracellular accumulation and an improved anticancer cytotoxicity when compared with free DOX, suggesting their potential as a nanoplatform for therapeutic delivery.