文献类型：专利

英文题名：New naphthalimide sugar-based compounds useful in fluorescent probe for detecting avian influenza virus (H5N1, H7N9 and H10N8) and human influenza virus (H1N1 and H3N2)

作者：CHEN G;HE X;ZENG Y;ZHOU D;LIN C;TANG X

机构：[1]UNIV EAST CHINA SCI & TECHNOLOGY

申请号：CN104844666-A

申请日：2015-03-31

公开日：2015-08-19

语种：英文

收录：DERWENT

摘要：NOVELTY - Naphthalimide sugar-based compounds (A) e.g. (2S,4R,5S)-5-acetamido-2-((3S,4R,5R)-2-((3R,4R,E)-6-((1-(2-(1,3-dioxo-6-(2-(4-(pyren-1-yl)butanamido)ethylamino)-1H-benzo(de)isoquinolin-2(3H)-yl)ethyl)-1H-1,2,3-triazol-4-yl)methoxyimino)-1,2,4-trihydroxyhexan-3-yloxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yloxy)-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydro-2H-pyran-2-carboxylic acid (I) are new. USE - (A) are useful in fluorescent probe for detecting avian influenza virus including H5N1, H7N9 or H10N8 and detecting human influenza virus including H1N1 and H3N2 (all claimed). DETAILED DESCRIPTION - Naphthalimide sugar-based compounds (A) i.e. (2S,4R,5S)-5-acetamido-2-((3S,4R,5R)-2-((3R,4R,E)-6-((1-(2-(1,3-dioxo-6-(2-(4-(pyren-1-yl)butanamido)ethylamino)-1H-benzo(de)isoquinolin-2(3H)-yl)ethyl)-1H-1,2,3-triazol-4-yl)methoxyimino)-1,2,4-trihydroxyhexan-3-yloxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yloxy)-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydro-2H-pyran-2-carboxylic acid of formula (I) and (3S,4S,5S)-5-acetamido-3-(((3S,4R,5S)-6-((3S,4R,5R,E)-6-((1-(2-(1,3-dioxo-6-(2-(4-(pyren-1-yl)butanamido)ethylamino)-1H-benzo(de)isoquinolin-2(3H)-yl)ethyl)-1H-1,2,3-triazol-4-yl)methoxyimino)-1,2,4,5-tetrahydroxyhexan-3-yloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)methoxy)-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydro-2H-pyran-3-carboxylic acid of formula (II) or their salts are new.