文献类型：期刊文献

英文题名：A fluorescent probe for imaging hydrogen peroxide in ovarian cancer cells

作者：Zhao, Peng;Wang, Kunyan;Zhu, Xiaomin;Zhou, Yuren;Wu, Junchen[1]

机构：[1]East China Univ Sci & Technol, Key Labs Adv Mat, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2018

卷号：155

起止页码：143

外文期刊名：DYES AND PIGMENTS

收录：;EI(收录号：20181404985532);WOS:【SCI-EXPANDED(收录号:WOS:000433650300020)】；

基金：We are grateful to NSFC/China (91529101, 21572057 and 21778017) for financial support.

语种：英文

外文关键词：Hydrogen peroxide; Fluorescence probe; Ovarian cancer cells

摘要：Hydrogen peroxide (H2O2) is an oxidative stress marker in various disease. The local concentration of H2O2 is related to cancer, a reliable and simple assay detecting H2O2 level in cells is therefore critical. Here, we have developed a fluorescence probe PEP-Npb1-Cy3 which can be used to detect H2O2 in living ovarian cancer cells. The probe is developed based on employing the oxide reactivity of 1, 8-naphthalimide boric acid towards H2O2, which yields a turn-on fluorescence signal and exhibits high selectivity and sensitivity. Our collective results support the applicability of PEP-Npb1-Cy3 as a powerful tool for imaging both exogenous and endogenous H2O2-involving biological events in ovarian cancer cells, which may have further biomedical applications.