文献类型：期刊文献

英文题名：Effect of the solvent on improving the recognition properties of surface molecularly imprinted polymers for precise separation of erythromycin

作者：Zhang, Yuxin[1,2,3];Qu, Xue[1,3];Wang, FeiFei[3];Wu, Gang[3];Li, Jinyang[3];Hong, Hua[3];Liu, Changsheng[1,2,3]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China

年份：2015

卷号：5

期号：102

起止页码：83619

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20154201394434);WOS:【SCI-EXPANDED(收录号:WOS:000362752400011)】；

基金：We acknowledge the financial support from Shanghai Natural Science Foundation (11ZR1409100), the National Natural Science Foundation of China (5110304, U1024209), the National Basic Research Program of China (973 Program, 2012CB933600), Innovation Program of Shanghai Municipal Education Commission (14ZZ060), the Fundamental Research Funds for the Central Universities (WD1214056) and Outstanding Youth Fund of East China University of Science and Technology (YD0157109).

语种：英文

外文关键词：Separation - Glass fibers - Molecules - Antibiotics

摘要：The formation of thin films with imprinting sites that can be accessed more rapidly by target molecules is an improvement in bulk molecular imprinting polymers. To achieve suitable properties for specific application, on the basis of our previous study of bulk erythromycin (ERY) imprinted polymers, we here rationally design, generate and test surface-imprinted polymers specific for ERY. ERY-A surface-imprinted glass fibers (GF-MIPs) were fabricated using glass fibers as the matrix, methacrylic acid (MAA) as the functional monomer, ethyleneglycol dimethacrylate (EGDMA) as the cross-linker and azobis(4-cyanovaleric acid) as the initiator. Then, we specifically studied the effect of the solvent on the recognition performance of the GF-MIPs. C-13-NMR and isothermal titration calorimetry (ITC) measurements were employed to demonstrate that the addition of NH3 center dot H2O can block the interactions between the -COOH group and the tertiary amine on ERY-A. The results of static adsorption and dynamic separation experiments also indicate that an increase of specificity can easily be obtained by mediating the solvent environment, thus satisfying the more stringent requirements of precise separation.