文献类型：期刊文献

英文题名：Development and Scale-up of the Rapid Synthesis of Triphenyl Phosphites in Continuous Flow

作者：Mao, Mengmei[1];Zhang, Le[1];Yao, Hanlin[1];Wan, Li[1];Xin, Zhong[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem Engn, Shanghai Key Lab Multiphase Mat Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem Engn, State Key Lab Chem Engn, Shanghai 200237, Peoples R China

年份：2020

卷号：5

期号：16

起止页码：9503

外文期刊名：ACS OMEGA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000529926400047)】；

基金：Fundamental Research Funds for the Central Universities (50321011917025, 50321012017025 and YA0127104).

语种：英文

摘要：A novel method for the synthesis of triphenyl phosphite and its derivatives has been developed in continuous flow. With a total residence time of 20 s, the target product was prepared in a microreactor, and the reaction time was significantly shortened compared with standard single batch reaction conditions. In addition, the reaction of various substrates gave the corresponding products in good to excellent yields under optimized conditions. The reactants could be employed in a stoichiometric ratio, making the reaction more efficient, economical, and environmentally friendly. In addition, scale-up apparatus was designed and assembled, and the kilogram-scale production (up to 18.4 kg/h) of tris(2,4-di-tert-butylphenyl) phosphite was achieved in 88% yield.