文献类型：期刊文献

英文题名：Harnessing microbial metabolomics for industrial applications

作者：Zhao, Jiachen[1];Wang, Guan[1];Chu, Ju[1];Zhuang, Yingping[1]

机构：[1]ECUST, State Key Lab Bioreactor Engn, Shanghai, Peoples R China

年份：2020

卷号：36

期号：1

外文期刊名：WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

收录：;EI(收录号：20195007824037);WOS:【SCI-EXPANDED(收录号:WOS:000501289600001)】；

基金：This work was financially subsidized by the National Natural Science Foundation of China [Grant No. 31900073], the Science and Technology Commission of Shanghai Municipality [Grant No. 19ZR1413600], the National Key Research and Development Program [Grant No. 2017ZX7402003] and the 111 Project [Grant No. B18022].

语种：英文

外文关键词：Industrial fermentation; Metabolomics; Metabolic engineering; Process optimization; System biology; Synthetic biology

摘要：Metabolome defines a set of metabolites present in a biological sample, which provides an immediate and dynamic recording of microbes in response to genetic and/or environmental perturbations. In recent years, metabolomics in combination with other omics diagnostic tools such as genomics, transcriptomics and proteomics is focused on addressing open biological questions that accelerate our understanding of the system as a whole and boost the use of systems metabolic engineering tools in industrial settings. In this review article, we summarize the applications of metabolomics to industrial microbial fermentations with respect to the bulk production of organic acids, amino acids, enzymes, antibiotics and therapeutic proteins. In addition, future prospects regarding metabolomics-assisted research are provided.