文献类型：期刊文献

英文题名：Tailored Engineering of Novel Xanthonium Polymethine Dyes for Synergetic PDT and PTT Triggered by 1064 nm Laser toward Deep-Seated Tumors

作者：Bian, Hui[1];Ma, Dandan[1];Zhang, Xinfu[1];Xin, Kai[2];Yang, Youjun[2];Peng, Xiaojun[1];Xiao, Yi[1]

机构：[1]Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2021

卷号：17

期号：21

外文期刊名：SMALL

收录：;EI(收录号：20211710257331);WOS:【SCI-EXPANDED(收录号:WOS:000642187800001)】；

基金：H.B. and D.M. contributed equally to this work. The author acknowledges the financial support from the National Natural Science Foundation of China (Nos. 21776037, 21901031, and 22078047), Dalian Science and Technology Innovation Fund (No. 2020JJ25CY014), Science and Technology Foundation of Liaoning Province (2020-YQ-08) and the Fundamental Research Funds for the Central Universities (No. DUT20RC(5)024). All animal research was conducted in accordance with approval from the Animal Ethics Committee of Dalian University of Technology (2018-043).

语种：英文

外文关键词：deep‐ seated tumors; NIR‐ II PDT; NIR‐ II PTT; small molecules; xanthonium polymethine dye

摘要：Small molecular dye that simultaneously exerts dual PDT/PTT effects as well as florescence imaging triggered by a single NIR-II light has never been reported to date. Apart from the huge challenge in pushing absorption profile into NIR-II region, fine-tuning dyes' excited state via rational structure design to meet all three functions, especially oxygen photosensitization, remains the most prominent throttle. Herein, five novel NIR-II dyes (BHs) are productively developed by strategically conjugating dyad innovative xanthonium with sequentially extended polymethine bridges, enabling intense absorption from 890 to 1206 nm, significantly 400 nm longer than conventional cyanine dyes with same polymethines. More importantly, owning to high resonance and favorable excited state energy population induced by greater rigidity via ring-fused amino, BH 1024 exhibits best singlet oxygen generation capability, moderate photothermal heating, and considerable fluorescence under 1064 nm laser irradiation. Furthermore, BH 1024 is encapsulated into folate-functionalized polymer, which demonstrated a synergetic PDT/PTT effect in vitro and in vivo, eventually achieving solid tumors elimination under NIR-II fluorescence guide. As far as it is known, this is the first time small molecular dyes for NIR-II PDT or NIR-II PDT/PTT are explored and designed.