文献类型：期刊文献

英文题名：Thiamine Hydrochloride-Catalyzed One-Pot Synthesis of 1,4-Dihydropyridine Derivatives Under Solvent-Free Conditions

作者：Lei, Min[1];Ma, Lei[1];Hu, Lihong[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China

年份：2011

卷号：41

期号：13

起止页码：1969

外文期刊名：SYNTHETIC COMMUNICATIONS

收录：;EI(收录号：20242616559988);WOS:【SCI-EXPANDED(收录号:WOS:000290409100011)，CCR-EXPANDED(收录号:WOS:000290409100011)】；

基金：This work was supported by the Chinese National Science and Technology Major Project, "Key New Drug Creation and Manufacturing Program" (Grants 2009ZX09301-001 and 2009ZX09102), the Chinese National High-Tech R&D Program (Grants 2007AA02Z147), the National Natural Science Foundation of China (Grants 90713046, 30772638, and 30925040), and the CAS Foundation (Grant KSCX2-YW-R-179).

语种：英文

外文关键词：Aldehydes; 1; 4-dihydropyridines; Hantzsch reaction; -keto ester; thiamine hydrochloride (VB1)

摘要：[image omitted] An efficient one-pot synthesis of 1,4-dihydropyridines from an aldehyde, -keto ester, and ammonium acetate or formamidine acetate using thiamine hydrochloride (VB1) as the catalyst under solvent-free conditions at ambient temperature is described. All types of aldehydes, including aromatic, aliphatic, and unsaturated aldehydes, give good yields. The catalyst can easily be recovered after completion of the reaction and reused without affecting its activity.