文献类型：期刊文献

英文题名：Oxidative stress and detoxification mechanisms of earthworms (Eisenia fetida) after exposure to flupyradifurone in a soil-earthworm system

作者：Qiao, Zhihua[1,2];Li, Peiyao[3];Tan, Jiaqi[4];Peng, Cheng[1];Zhang, Fengwen[2,5];Zhang, Wei[1];Jiang, Xingyin[2]

机构：[1]East China Univ Sci & Technol, Sch Resource & Environm Engn, State Environm Protect Key Lab Environm Risk Asses, Shanghai 200237, Peoples R China;[2]Shandong Agr Univ, Coll Plant Protect, Key Lab Pesticide Toxicol & Applicat Tech, Tai An 271018, Shandong, Peoples R China;[3]Qingdao Agr Univ, Coll Agr, Qingdao 266109, Shandong, Peoples R China;[4]Louisiana State Univ, Dept Biol Sci, Baton Rouge, LA 70803 USA;[5]Chinese Acad Agr Sci CAAS, Tobacco Res Inst, Qingdao 266101, Shandong, Peoples R China

年份：2022

卷号：322

外文期刊名：JOURNAL OF ENVIRONMENTAL MANAGEMENT

收录：;EI(收录号：20233314558309);WOS:【SCI-EXPANDED(收录号:WOS:000863224400004)】；

基金：This research was supported by the National Natural Science Foundation of China (41877124, 21737005) , the National Modern Agricultural Technology & Industry System (SDAIT-02-10) , the Provincial Major Technological Innovation Program of Agricultural Application in Shandong, and the Shandong "double first-class" award (SYL2017- XTTD11) .

语种：英文

外文关键词：Flupyradifurone; Earthworm; Transcriptomics; Antioxidant system; Toxicity mechanisms

摘要：Flupyradifurone (FLU) has great application potential in agricultural production as a new generation of neonicotinoid insecticide after imidacloprid. Nevertheless, the toxic effects of FLU on non-target soil organisms remain unclear, resulting in considerable environmental risks. We evaluated the acute and subchronic toxicities of FLU to earthworms. The results of acute toxicity show that the median lethal concentration (LC50) values (14 d) of FLU were 186.9773 mg kg(-1) for adult earthworms and 157.6502 mg kg(-1 )for juveniles, respectively. The subchronic toxicity of FLU that focused on the activities of antioxidant and detoxication enzymes showed the superoxide dismutase (SOD), catalase (CAT), and glutathione-S transferase (GST) activities in earthworms increased while the peroxidase (POD) and acetylcholinesterase (AChE) activities decreased after exposure to FLU. Oxidative damage analyses revealed that the reactive oxygen species (ROS) level and malonaldehyde (MDA) content in earthworms were increased by FLU, resulting in DNA damage. Transcriptomics and RT-qPCR confirmed that FLU influenced the expression of genes related to antioxidant response and detoxification of earthworms. Ultimately detoxification metabolism, environmental information processing, cell processes, and immune system pathways are significantly enriched to respond jointly to FLU. Our study fills the gaps in the toxicity of FLU to earthworms, providing a basis for its risk assessment of soil ecosystems and non-target biological toxicity.