文献类型：会议论文

英文题名：Preparation and osteogenic properties of magnesium calcium phosphate biocement scaffolds for bone regeneration

作者：Li, X.[1]; Niu, Y.[2]; Guo, H.[3]; Chen, H.[1]; Li, F.[4]; Zhang, J.[1]; Chen, W.[4]; Wu, Z.[1]; Deng, Y.[1]; Wei, J.[1]; Liu, C.[1]

机构：[1] Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China; [2] Department of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; [3] Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China; [4] Department of Pharmaceutics, Shanghai 8th People's Hospital, Shanghai 200235, China

语种：英文

外文关键词：Biocompatibility - Calcium phosphate - Scaffolds - X ray radiography - Radiation effects - Image reconstruction - Synchrotron radiation - Synchrotrons - Compressive strength - Defects - Bone - Magnesium compounds

摘要：The regenerative treatment of large osseous defects remains a formidable challenge in today. In the present study, we have synthesized biodegradable magnesium calcium phosphate biocement (MCPB) scaffolds with interconnected macroporous structure (100-600 μm), as well as good bioactivity, biocompatibility and proper degradatibility. The results revealed that the porosity increased from 52% to 80% of MCPB scaffolds while the compressive strength decreased from 6.1 MPa to 1.2 MPa. We further assessed the effects of scaffolds on the rabbit femur cavity defect model in vivo by using synchrotron radiation X-ray microCT and microCT imaging, indicating that the MCPB scaffolds underwent gradually degradation and promoted the extensive neo-bone formation. ? 2013 IOP Publishing Ltd and Sissa Medialab srl.