文献类型：期刊文献

英文题名：Rhodium(II)-Catalyzed Reaction of 1-Tosyl-1,2,3-triazoles with Morita-Baylis-Hillman Adducts: Synthesis of 3,4-Fused Pyrroles

作者：Jia, Renmeng[1,2];Meng, Jiang[1,2];Leng, Jiaying[1,2];Yu, Xingxin[1,2];Deng, Wei-Ping[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2018

卷号：13

期号：17

起止页码：2360

外文期刊名：CHEMISTRY-AN ASIAN JOURNAL

收录：;EI(收录号：20181104896741);WOS:【SCI-EXPANDED(收录号:WOS:000443679400016)】；

基金：This work is supported by the National Natural Science Foundation of China (No. 21402049).

语种：英文

外文关键词：pyrroles; rhodium catalyzed; synthetic methods; triazoles

摘要：A cascade reaction of rhodium azavinylcarbenes with Morita-Baylis-Hillman (MBH) adducts enables a novel synthetic approach to 3,4-fused pyrroles. The cascade reaction begins with the insertion of O-H bond into rhodium azavinylcarbenes, subsquent sigmatropic rearrangement provides substituted ,-unsaturated cyclic ketone intermediates. Then the intramolecular aza Michael addition/oxidative aromatization sequence give rise to a wide range of 3,4-fused pyrroles in good yields, and with excellent functional group compatibility.