文献类型：期刊文献

英文题名：Palladium-catalyzed site-selective direct olefination of 6-electron-withdrawing group substituted 3-arylbenzo[d] isoxazoles

作者：Guo, Ying[1];Shao, Ling-Yan[1];Yu, Kun-Kun[1];Hu, Ya-Hua[1];Liu, Hong-Wei[1];Liao, Dao-Hua[1];Ji, Ya-Fei[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2017

卷号：4

期号：10

起止页码：1962

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：;EI(收录号：20184806137254);WOS:【SCI-EXPANDED(收录号:WOS:000411716700010)，CCR-EXPANDED(收录号:WOS:000411716700010)】；

基金：We gratefully thank the National Natural Science Foundation of China (Project No. 21476074 and 21676088) for financial support.

语种：英文

外文关键词：Palladium

摘要：A palladium-catalyzed direct olefination of 6-electron-withdrawing group substituted 3-arylbenzo[d] isoxazoles has been developed with exclusive site-selectivity and excellent E-stereoselectivity. It was found that the olefination occurred at the acidic C-7 position only, overriding a potential directing-group assisted bias. With the wide range of alkene patterns, the protocol allows convenient access to multifarious C-7 olefinated benzo[d] isoxazoles in moderate to good yields.