文献类型：期刊文献

英文题名：A novel strategy for the aqueous synthesis of down-/up-conversion nanocomposites for dual-modal cell imaging and drug delivery

作者：Zhao, Peng[1];Zhang, Jing[2];Zhu, Yihua[1];Yang, Xiaoling[1];Jiang, Xin[1];Yuan, Yuan[2];Liu, Changsheng[2];Li, Chunzhong[1]

机构：[1]E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2014

卷号：2

期号：47

起止页码：8372

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20144600208233);WOS:【SCI-EXPANDED(收录号:WOS:000345090700012)】；

基金：This work was supported by the National Natural Science Foundation of China (21471056, 21236003, 21206042, and 21176083), the Basic Research Program of Shanghai (13NM1400700, 13NM1400701), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Molecular biology - Semiconductor quantum dots - Ytterbium compounds - Diseases - Luminescence - Silver compounds - Controlled drug delivery - Targeted drug delivery - Uranium compounds - II-VI semiconductors - Sodium compounds

摘要：A highly efficient multifunctional nanoplatform for dual-modal luminescence imaging and pH-responsive drug delivery has been developed on the basis of a facile and novel strategy by covalently binding up-conversion (UC) luminescent NaYF4:Yb,Er nanoparticles with down-conversion (DC) fluorescent AgInS2-ZnS quantum dots. Due to the enriched carboxylic groups in the polymer shell of UC nanoparticles, the as-prepared nanocomposites (NCs) are water-soluble, functionalizable and able to load anti-cancer drug molecules, doxorubicin (DOX), by simple physical adsorption. The release of DOX from NCs was controlled by varying the pH, with an increased drug dissociation rate in an acidic environment, favorable for controlled drug release. Moreover, the endocytosis and the efficient drug release properties of the system were confirmed by luminescence microscopy. Hence, this approach provides a valuable method for fabricating a NC system with highly integrated functionalities for dual-modal luminescence cell imaging and targeted cancer therapy.