文献类型：期刊文献

英文题名：A Conformable and Tough Janus Adhesive Patch with Limited 1D Swelling Behavior for Internal Bioadhesion

作者：Chen, Kai[1];Liu, Chenyu[1];Huang, Jinghuan[2];Che, Lingbin[3];Yuan, Yuan[1];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Engn Res Ctr Biomed Mat, Sch Mat Sci & Engn,Minist Educ,Key Lab Ultrafine M, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Sch Med, Shanghai 200233, Peoples R China;[3]Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Orthoped, Sch Med, Shanghai 200080, Peoples R China

年份：2023

卷号：33

期号：41

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20232414246732);WOS:【SCI-EXPANDED(收录号:WOS:001004036400001)】；

基金：Acknowledgements The authors wish to express their gratitude to the financial supports from the Basic Science Center Project of National Natural Science Foundation of China (T2288102), the National Natural Science Foundation of China (No. 31971264 and No. 32271401), National Key R&D Program of China (SQ2022YFC2400481) and Program of Shanghai Academic/Technology Research Leader (22XD1433900). The authors would like to thank Figdraw for the support of partial scheme materials.

语种：英文

外文关键词：conformable and tough biointerfaces; fast water absorption; Janus adhesive patches; limited 1D swelling; postoperative anti-adhesion

摘要：Advanced bioadhesion techniques have offered unprecedented opportunities for life-saving internal surgical procedures. However, most existing bioadhesives failed to rapidly establish long-lasting reliable biointerface and effectively reconstruct normal physiological function in the body fluid-rich and inevitable dynamic internal environment. Herein, a PEGylated poly(glycerol sebacate)-based Janus adhesive patch (PEGS-based JAP) is developed by integrating physically crosslinked guanidinylated PEGS (PEGSG) and acryloylated PEGS-chemically crosslinked poly(acrylic acid)-N-hydrosuccinimide ester (PEGSA-crosslinked PAAc-NHS) with a single-sided zwitterionic polymer-interpenetrated layer. The dry JAP can rapidly absorb the unpleasant interfacial water and effectively form strong physical interactions with wet tissues. Benefiting from the amphiphilic nature of PEGSG and a simple spatial-confined drying process, the JAP is allowed to resist excessive swelling and limitedly swell along one direction to avoid deterioration of the as-established conformable patch-tissue interface. Moreover, covalent interactions formed subsequently can further improve the adhesive strength and ensure a long-lasting reliable adhesion. Meanwhile, the notch-insensitive and puncture-resistant JAP can achieve tough adhesion to adapt to the dynamic conditions owing to the highly efficient energy-dissipation mechanism of the physically cross-linked network. Combining the above ideal features with the desirable postoperative anti-adhesion ability, the PEGS-based JAP is demonstrated to be a promising candidate for internal tissue adhesion and function reconstruction.