文献类型：期刊文献

英文题名：Co-exposure of decabromodiphenyl ethane and cadmium increases toxicity to earthworms: Enrichment, oxidative stress, damage and molecular binding mechanisms

作者：Qiao, Zhihua[1];Sun, Xinlin[2];Fu, Mengru[1];Zhou, Shanqi[1];Han, Yanna[1];Zhao, Xuan[1];Gong, Kailin[1];Peng, Cheng[1];Zhang, Wei[1];Liu, Fang[3];Ye, Chunmei[3];Yang, Jie[3]

机构：[1]East China Univ Sci & Technol, Sch Resource & Environm Engn, State Environm Protect Key Lab Environm Risk Asses, Shanghai 200237, Peoples R China;[2]Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China;[3]Shanghai Acad Environm Sci, State Environm Protect Engn Ctr Urban Soil Contami, Shanghai 200233, Peoples R China

年份：2024

卷号：473

外文期刊名：JOURNAL OF HAZARDOUS MATERIALS

收录：;EI(收录号：20242116138223);WOS:【SCI-EXPANDED(收录号:WOS:001245035500001)】；

基金：This research was supported by the Special Fund of State Environmental Protection Engineering Center for Urban Soil Contamination Control and Remediation (USCR-202206) , and the National Natural Science Foundation of China (41877124) .

语种：英文

外文关键词：Decabromodiphenyl ethane; Cadmium; Earthworm; Toxicity; Molecular binding

摘要：The increase of electronic waste worldwide has resulted in the exacerbation of combined decabromodiphenyl ethane (DBDPE) and cadmium (Cd) pollution in soil, posing a serious threat to the safety of soil organisms. However, whether combined exposure increases toxicity remains unclear. Therefore, this study primarily investigated the toxic effects of DBDPE and Cd on earthworms at the individual, tissue, and cellular levels under single and combined exposure. The results showed that the combined exposure significantly increased the enrichment of Cd in earthworms by 50.32-90.42 %. The toxicity to earthworms increased with co-exposure, primarily resulting in enhanced oxidative stress, inhibition of growth and reproduction, intensified intestinal and epidermal damage, and amplified coelomocyte apoptosis. PLS-PM analysis revealed a significant and direct relationship between the accumulation of target pollutants in earthworms and oxidative stress, damage, as well as growth and reproduction of earthworms. Furthermore, IBR analysis indicated that SOD and POD were sensitive biomarkers in earthworms. Molecular docking elucidated that DBDPE and Cd induced oxidative stress responses in earthworms through the alteration of the conformation of the two enzymes. This study enhances understanding of the mechanisms behind the toxicity of combined pollution and provides important insights for assessing e -waste contaminated soils.