文献类型：期刊文献

英文题名：Injectable nanofiber-reinforced bone cement with controlled biodegradability for minimally-invasive bone regeneration

作者：Cai, Peihao[1];Lu, Shunyi[2];Yu, Jieqin[2];Xiao, Lan[3];Wang, Jiayi[2];Liang, Haifeng[2];Huang, Lei[2];Han, Guanjie[2];Bian, Mengxuan[2];Zhang, Shihao[1];Zhang, Jian[2];Liu, Changsheng[1];Jiang, Libo[2];Li, Yulin[1]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Engn Res Ctr Biomed Mat, Sch Mat Sci & Engn,Minist Educ,Key Lab Ultrafine M, Shanghai 200237, Peoples R China;[2]Fudan Univ, Zhongshan Hosp, Dept Orthopaed Surg, Shanghai 200032, Peoples R China;[3]Queensland Univ Technol, Ctr Biomed Technol, Sch Mech Med & Proc Engn, Brisbane 4059, Australia

年份：2023

卷号：21

起止页码：267

外文期刊名：BIOACTIVE MATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000862504000001)】；

基金：The research was supported by the National Key R&D Program of China (2018YFE0201500), the National Natural Science Foundation of China (81772317, 82272457 and 51973060), the National Natural Science Foundation of China for Innovative Research Groups (51621002). This work was also supported by "Technology Innovation Action Plan" of Shanghai Science and Technology Commission (21S11902700), Natural Science Foundation of Shanghai (21ZR1412300), Shanghai Talent Development Fund (2020067), Shanghai "Rising Stars of Medical Talent" Youth Development Program (Youth Medical Talents - Specialist Program, [2020]087).

语种：英文

外文关键词：Injectable calcium phosphate cement; Biodegradable PLGA nanofiber; Angiogenesis; Osseointegration; Minimally-invasive bone regeneration

摘要：Injectable materials show their special merits in regeneration of damaged/degenerated bones in minimally -invasive approach. Injectable calcium phosphate bone cement (CPC) has attracted broad attention for its bioactivity, as compared to non-degradable polymethyl methacrylate cement. However, its brittleness, poor anti -washout property and uncontrollable biodegradability are the main challenges to limit its further clinical application mainly because of its stone-like dense structure and fragile inorganic-salt weakness. Herein, we developed a kind of injectable CPC bone cement with porous structure and improved robustness by incorporating poly(lactide-co-glycolic acid) (PLGA) nanofiber into CPC, with carboxymethyl cellulose (CMC) to offer good injectability as well as anti-wash-out capacity. Furthermore, the introduction of PLGA and CMC also enabled a formation of initial porous structure in the cements, where PLGA nanofiber endowed the cement with a dynamically controllable biodegradability which provided room for cell movement and bone ingrowth. Inter-estingly, the reinforced biodegradable cement afforded a sustainable provision of Ca2+ bioactive components, together with its porous structure, to improve synergistically new bone formation and osteo-integration in vivo by using a rat model of femur condyle defect. Further study on regenerative mechanisms indicated that the good minimally-invasive bone regeneration may come from the synergistic enhanced osteogenic effect of calcium ion enrichment and the improved revascularization capacity contributed from the porosity as well as the lactic acid released from PLGA nanofiber. These results indicate the injectable bone cement with high strength, anti -washout property and controllable biodegradability is a promising candidate for bone regeneration in a minimally-invasive approach.