文献类型：期刊文献

英文题名：G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders

作者：Wong, Thian-Sze[1,2];Li, Guangzhi[3];Li, Shiliang[4,5];Gao, Wei[1,5];Chen, Geng[1];Gan, Shiyi[1];Zhang, Manzhan[4,5];Li, Honglin[4,5];Wu, Song[3,6];Du, Yang[1]

机构：[1]Chinese Univ Hong Kong, Kobilka Inst Innovat Drug Discovery, Sch Med, Shenzhen Key Lab Steroid Drug Discovery & Dev, Shenzhen 518172, Guangdong, Peoples R China;[2]Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China;[3]Shenzhen Univ, Affiliated Luohu Hosp, Inst Urol, Shenzhen 518000, Guangdong, Peoples R China;[4]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[5]East China Normal Univ, Innovat Ctr AI & Drug Discovery, Shanghai 200062, Peoples R China;[6]Shenzhen Univ, South China Hosp, Hlth Sci Ctr, Dept Urol, Shenzhen 518116, Guangdong, Peoples R China

年份：2023

卷号：8

期号：1

外文期刊名：SIGNAL TRANSDUCTION AND TARGETED THERAPY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000981919100002)】；

基金：The project is supported by grants from Science, Technology and Innovation Commission of Shenzhen Municipality (Project code JCYJ20200109150019113, GXWD20201231105722002); the Kobilka Institute of Innovative Drug Discovery and Presidential Fellowship at the Chinese University of Hong Kong, Shenzhen, China; National Natural Science Foundation of China (Project code 32271263 to Y.D., Project code 82173690 to S.L., 81825020 and 82150208 to H.L.); and the Lingang Laboratory (Project code LG-QS-202206-02 to S.L.)

语种：英文

摘要：Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors. Identifying treatment targets is challenging because the diseases are resulting from heterogeneous biological, genetic, and environmental factors. Nevertheless, the increasing understanding of G protein-coupled receptor (GPCR) opens a new possibility in drug discovery. Harnessing our knowledge of molecular mechanisms and structural information of GPCRs will be advantageous for developing effective drugs. This review provides an overview of the role of GPCRs in various neurodegenerative and psychiatric diseases. Besides, we highlight the emerging opportunities of novel GPCR targets and address recent progress in GPCR drug development.