文献类型：期刊文献

中文题名：Enantioselective Morita-Baylis-Hillman Reaction Organocatalyzed by Glucose-based Phosphinothiourea

英文题名：Enantioselective Morita-Baylis-Hillman Reaction Organocatalyzed by Glucose-based Phosphinothiourea

作者：Yang Weihong;Sha Feng;Zhang Xin;Yuan Kui;Wu Xinyan[1]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2012

卷号：30

期号：11

起止页码：2652

中文期刊名：Chinese Journal of Chemistry

外文期刊名：CHINESE JOURNAL OF CHEMISTRY

收录：;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000311169300011)，CCR-EXPANDED(收录号:WOS:000311169300011)】；CSCD:【CSCD2011_2012】；

基金：We are grateful for the financial support from the National Natural Science Foundation of China (No. 20772029), the Program for New Century Excellent Talents in University (No. NCET-07-0286) and the Fundamental Research Funds for the Central Universities.

语种：英文

中文关键词：asymmetric organocatalysis;Morita-Baylis-Hillman reaction;bifunctional phosphine;chiral phosphi-nothiourea;acrylate

外文关键词：asymmetric organocatalysis; Morita-Baylis-Hillman reaction; bifunctional phosphine; chiral phosphinothiourea; acrylate

摘要：A class of bifunctional phosphinothioureas derived from saccharide was developed as new organocatalysts for the enantioselective Morita-Baylis-Hillman reaction between acrylates and aldehydes. With 10 mol% of glucose- based phosphinothiourea ld, the allylic alcohols were obtained in up to 96% yield and 83% ee under mild reaction conditions.
A class of bifunctional phosphinothioureas derived from saccharide was developed as new organocatalysts for the enantioselective Morita-Baylis-Hillman reaction between acrylates and aldehydes. With 10 mol% of glucose-based phosphinothiourea 1d, the allylic alcohols were obtained in up to 96% yield and 83% ee under mild reaction conditions.