文献类型：期刊文献

英文题名：Advance and Designing Strategies in Polymeric Antifungal Agents Inspired by Membrane-Active Peptides

作者：Jiang, Weinan[1];Wu, Yueming[2];Zhou, Min[3];Song, Gonghua[3];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Res Ctr Biomed Mat,Key Lab Ultra Fine Mat,Frontie, Minist Educ,Shanghai Frontier Sci Res Base Optoge, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2022

卷号：28

期号：65

外文期刊名：CHEMISTRY-A EUROPEAN JOURNAL

收录：;EI(收录号：20223812767803);WOS:【SCI-EXPANDED(收录号:WOS:000853914100001)】；

基金：This research was supported by the National Natural Science Foundation of China (No. 22075078, 21861162010), Free exploring basic research project at Shenzhen Research Institute of ECUST (2021Szvup042), Program of Shanghai Academic/Technology Research Leader (20XD1421400), China National Postdoctoral Program for Innovative Talents (BX2021102, BX20220108), the China Postdoctoral Science Foundation (2021M701198, 2022M710050).

语种：英文

外文关键词：antifungal polymer; cell-penetrating peptides; drug resistance; host defense peptides; peptidomimetics

摘要：The high-mortality invasive fungal infections seriously threaten the lives of immunocompromised people. Host defense peptides and cell-penetrating peptides are representative membrane-active peptides with different functions. Among them, host defense peptides mimicking is a valid strategy in the design of synthetic antifungal agents. Despite the brilliance in the field of intracellular delivery, the potential of cell-penetrating peptides and their mimics for designing antifungal agents has been overlooked. In this concept article, we describe the structural design of synthetic antifungal polymers as mimics of host defense peptides, and highlight the effectiveness and potential of cell-penetrating peptide-inspired strategy in designing potent and selective antifungal polymeric agents. In addition, an outlook for further expanding the design horizons of antifungal polymers is also presented.