文献类型：期刊文献

英文题名：Determination of enantiomeric purity of (S)-(-)-α-phenylethylamine by NMR

作者：Jiang, XD; Su, KM; Cai, SH

机构：[1]ECUST, Petrochem Inst, Shanghai 201512, Peoples R China;[2]E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Dept Chem Engn, Shanghai 200237, Peoples R China

年份：2001

卷号：21

期号：3

起止页码：404

外文期刊名：SPECTROSCOPY AND SPECTRAL ANALYSIS

收录：;EI(收录号：2004057991158);WOS:【SCI-EXPANDED(收录号:WOS:000170530200042)】；

语种：英文

外文关键词：NMR; enantiomeric purities; chiral solvating agents

摘要：It was reported the determination of enantiomeric purities of (S)-(-)-alpha -phenylethylamine by H-1 NMR, using (2R, 3R)dibenzoyl-tartaric acid as chiral solvating agent. H-1 NMR chemical shift non-equivalence of the methyl doublet of alpha -phenylethylamine was 0.08 ppm(base-line separation) in solvent CDCl3,when the concentration of the sample was 0.051 mol.L-1 the molar ratio between chiral solvating agent and the sample was 0.33. The enantiomeric purities could be determined by the peak areas of the methyl doublet of a - phenylethylamine. The relative standard deviation depended upon the enantiomeric purities of sample. With enantiomeric purities as high as 99.1% ee, the RSD was 0.3% (n = 4).