文献类型：期刊文献

英文题名：Synthesis of novel nithiazine analogues containing the 1,4-dihydropyridine structure, and their bioactivity as insecticides

作者：Tian, Zhongzhen[1];Cui, Shuxia[1];Xu, Zhiping[2]

机构：[1]Univ Jinan, Sch Chem & Chem Engn, Shandong Prov Key Lab Fluorine Chem & Chem Mat, Jinan 250022, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2014

卷号：40

期号：3

起止页码：1053

外文期刊名：RESEARCH ON CHEMICAL INTERMEDIATES

收录：;EI(收录号：20141817645945);WOS:【SCI-EXPANDED(收录号:WOS:000331001800010)】；

基金：We thank the National Science Foundation China Program (grant 20902037), the Promotive Research Fund for Excellent Young and Middle-aged Scientists of Shandong Province (grant BS2010NY001), and the Opening Fund of Shanghai Key Laboratory of Chemical Biology (grant SKLCB-2008-08).

语种：英文

外文关键词：Nithiazine; Neonicotinoid insecticides; 1,4-Dihydropyridine; Biological activity

摘要：A series of novel nithiazine analogues bearing the 1,4-dihydropyridine structure have been designed and synthesized by reaction of nithiazine, malononitrile or ethyl cyanoacetate, and benzaldehyde. The synthesized compounds were identified by H-1 NMR and IR spectroscopy, and elemental analysis. Preliminary bioassays indicated that most of the compounds had moderate insecticidal activity against Aphis craccivora. The relationship between molecular structure and biological activity is discussed.