文献类型：期刊文献

英文题名：Lanthanide triflate catalyzed one-pot synthesis of dihydropyrimidin-2(1H)-thiones by a three-component of 1,3-dicarbonyl compounds, aldehydes, and thiourea using a solvent-free Biginelli condensation

作者：Wang, Limin[1]; Qian, Changtao[2]; Tian, He[1]; Ma, Yun[3]

机构：[1]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Organomet Chem Lab, Shanghai 200032, Peoples R China;[3]Cornell Univ, Dept Chem, Ithaca, NY 14853 USA

年份：2003

卷号：33

期号：9

起止页码：1459

外文期刊名：SYNTHETIC COMMUNICATIONS

收录：;EI(收录号：20242716594610);WOS:【SCI-EXPANDED(收录号:WOS:000182804500005)，CCR-EXPANDED(收录号:WOS:000182804500005)】；

语种：英文

外文关键词：lanthanide triflate; Biginelli reaction; one-pot synthesis; dihydropyrimidin-2(1H)-thiones

摘要：Novel one-pot Biginelli-type reaction has been developed. Aromatic and aliphatic aldehydes with beta-dicarbonyl compounds and thiourea in the presence of catalytic amount 5 mol% of Yb(OTf)3 at 100degrees C for 60-90 min under solvent-free conditions proceeded smoothly to afford corresponding dihydropyrimidin-thiones. The yields of the classical Biginelli reaction can be increased from 20-50% to 81-91 % while the reaction time was shortened from 18-48 h to 60-90 min. In addition the catalyst can be easily recovered and reused.