文献类型：期刊文献

英文题名：Asymmetric Construction of Spirocyclic Pyrrolidine-thia(oxa)zolidinediones via N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with 5-Alkylidene Thia(oxa)zolidine-2,4-diones

作者：Yang, Wu-Lin;Tang, Fei-Fei;He, Fu-Sheng;Li, Chun-Yan;Yu, Xingxin[1];Deng, Wei-Ping

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2015

卷号：17

期号：19

起止页码：4822

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000362384700044)，CCR-EXPANDED(收录号:WOS:000362384700044)】；

基金：This work is supported by The Fundamental Research Funds for the Central Universities, the National Natural Science Foundation of China (No. 21172068), Shanghai Pujiang Program (No. 14PJD013), and Shanghai Yangfan Program (No. 14YF1404600).

语种：英文

摘要：A highly efficient asymmetric 1,3-dipolar cycloaddition of azomethine ylides to S-alkylidene thia(oxa)zolidine-2,4-diones catalyzed by a chiral N,O-ligand/Cu(CH3CN)(4)BF4 system is reported, affording structurally novel spirocyclic pyrrolidine-thia(oxa)zolidinediones with a spiro-heteroquaternary stereogenic center in good to excellent yields (up to 99%), with excellent levels of diastereo- and enantioselectivity (dr up to 99:1; ee up to 98%).