文献类型：期刊文献

英文题名：Catalytic α-hydroxylation of ketones under CuBr2 or HBr/DMSO systems

作者：Li, Hong-Liang;An, Xing-Lan;Ge, Li-Shi;Luo, Xiaoyan[1];Deng, Wei-Ping

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2015

卷号：71

期号：21

起止页码：3247

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000355031000009)】；

基金：This work was financially supported by the Fundamental Research Funds for the Central Universities and the National Natural Science Foundation of China (No. 21172068), and Shanghai Committee of Science and Technology (No. 14431902500).

语种：英文

外文关键词：alpha-Hydroxyketones; CuBr2; HBr; DMSO

摘要：An efficient and facile alpha-hydroxylation of ketones catalyzed by CuBr2 or HBr in DMSO is developed, providing secondary/tertiary alpha-hydroxy carbonyl compounds in moderate to good yields (up to 87%). A series of control experiments suggested that water and DMSO may work cooperatively in the hydrolysis step. (C) 2015 Elsevier Ltd. All rights reserved.