文献类型：期刊文献

英文题名：Characterization of glyphosate-induced cardiovascular toxicity and apoptosis in zebrafish

作者：Lu, Jian[1];Wang, Weiguo[1];Zhang, Cheng[2];Xu, Wenping[1];Chen, Weidong[1];Tao, Liming[1];Li, Zhong[1];Cheng, Jiagao[1];Zhang, Yang[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]UT southwestern Med Ctr, Dept Pathol, Dallas, TX 75390 USA

年份：2022

卷号：851

外文期刊名：SCIENCE OF THE TOTAL ENVIRONMENT

收录：;EI(收录号：20223612689676);WOS:【SCI-EXPANDED(收录号:WOS:000863254000017)】；

基金：Acknowledgements This work was fi nancial sponsored by Shanghai Sailing Program (NO.19YF1411100) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Glyphosate; Developmental toxicity; Heart; Vascular; Apoptosis; Zebra fish

摘要：Glyphosate, the most widely used herbicide, presents new hazards to human health. The developmental toxicity of glyphosate, especially its cardiovascular toxicity, needs to be closely monitored. To understand how glyphosate affects development, we performed toxicity tests on zebrafish embryos that were continuously exposed to glyphosate. The re-sults indicated that glyphosate affected the overall development of zebrafish embryos, including mortality, hatching abnormalities, and decreased body length. At the same time, zebrafish embryos exposed to glyphosate exhibited car-diac malformations, including enlarged chambers, thinned ventricular walls, and rhythm disturbances. In addition, de-fective intersegmental vasculature occurred after glyphosate exposure, indicating impaired angiogenesis. Mechanistically, apoptosis clustered in the heart and vascular regions and levels of ATP and apoptosis-related genes including caspase-3, caspase-9, bax, and bcl-2 were altered. In summary, the data showed that cardiovascular toxicity caused by glyphosate exposure may be related to apoptosis. Our study provides evidence for a link between glyphosate exposure and cardiovascular developmental toxicity. This raises concerns regarding the health risks of the glyphosate.