文献类型：期刊文献

英文题名：Preparation of molecularly imprinted polymers for artemisinin based on the surfaces of silica gel

作者：Gong, Xiao-Yan[1];Cao, Xue-Jun[1]

机构：[1]E China Univ Sci & Technol, Dept Biochem Engn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2011

卷号：153

期号：1-2

起止页码：8

外文期刊名：JOURNAL OF BIOTECHNOLOGY

收录：;EI(收录号：20111813955971);WOS:【SCI-EXPANDED(收录号:WOS:000290208000002)】；

基金：This project was financially supported by Natural Scientific Foundation of China (20676032).

语种：英文

外文关键词：Artemisinin; Surface molecularly imprinted polymers; Silica gel

摘要：Artemisinin is an effective antimalarial drug isolated from the herbal medicine Artemisia annua L. Molecular imprinting is a technique of preparing molecularly imprinted polymers (MIPs) which can specifically recognize the imprinted template molecules. In this work, silica gel were used as supporting matrix, and vinyltriethoxysilane (VTES) was grafted onto its surface. The preparation of MIPs for artemisinin was performed on the surfaces of the modified silica gel using artemisinin as the template, acrylamide (AM) and methacrylic acid (MAA) as the functional monomers, ethylene glycol dimethacrylate (EGDMA) as the cross-linker and 2,2'-azo-bis-isobutyronitrile (AIBN) as the initiator. Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR) and pore size analysis were used to characterize the prepared MIPs. The adsorption kinetic curve, adsorption isotherm and selective adsorption were measured by static method. The adsorption reached equilibrium at about 10 h, while fast adsorption took place during the first 2-3 h. The maximum adsorption capacity has been found to be 37.13 mg/g according to calculation with Langmuir-Freundlich isotherm. The electivity coefficients of MIPs for artemisinin with respect to artemether and arteether were 2.88 and 3.38, respectively. The results showed that the MIPs possessed good specific adsorption capacity and selectivity for artemisinin. (C) 2011 Elsevier B.V. All rights reserved.