文献类型：期刊文献

英文题名：Preparation and characterization of mPEG grafted chitosan micelles as 5-fluorouracil carriers for effective anti-tumor activity

作者：Fu, Dong-Jun[1];Jin, Yu[1];Xie, Mu-Qing[1];Ye, Ya-Jing[1];Qin, Dong-Dong[1];Lou, Kai-Yan[1,2,3];Chen, Yan-Zuo[1];Gao, Feng[1,2,3]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab Funtt Mat Chem, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2014

卷号：25

期号：11

起止页码：1435

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000345489500007)】；

基金：The authors acknowledge the financial support from the Fundamental Research Funds for the Central Universities (No. WY1213013ECUST). This work was also supported by Science and Technology Commission of Shanghai Municipality (STCSM, contract Nos.11DZ2260600 and 10DZ2220500).

语种：英文

外文关键词：Self-assembled micelles; Methoxy polyethylene glycol grafted chitosan; 5-Fluorouracil; Controlled-release

摘要：The objective of this study was to investigate the potential of methoxy polyethylene glycol (mPEG) grafted chitosan (mPEG-g-CS) to be used as a drug carrier. mPEG-g-CS was successfully synthesized by one-step method with formaldehyde. The substitution degree of mPEG on chitosan was calculated by elemental analysis and was found to be (3.23 +/- 0.25)%. mPEG-g-CS self-assembled micelles were prepared by ultrasonic method with the controlled size of 178.5-195.1 nm and spherical morphology. Stable dispersion of the micelles was formed with the zeta potential of 2.3-30.2 mV. 5-Fluorouracil (5-FU), an anticancer chemotherapy drug, was used as a model drug to evaluate the efficiency of the new drug delivery carrier. The loading efficiency of 5-FU was (4.01 +/- 0.03)%, and the drug-loaded mPEG-g-CS self-assembled micelle showed a controlled-release effect. In summary, the mPEG-g-CS self-assembled micelle is proved to be a promising carrier with controlled particle size and controlled-release effect. Therefore, it has great potential for the application as 5-FU carriers for effective anti-tumor activity. (C) 2014 Feng Gao. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.