文献类型：期刊文献

英文题名：Enantioselective synthesis of spiro[indoline-3,4′-pyrano[2,3-c]pyrazole] derivatives via an organocatalytic asymmetric Michael/cyclization cascade reaction

作者：Xie, Jin[1,2];Xing, Xiao-Yu[1,2];Sha, Feng[1,2];Wu, Zhi-Yan[3];Wu, Xin-Yan[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Quanzhou High Sch, Guilin 541500, Guangxi, Peoples R China

年份：2016

卷号：14

期号：35

起止页码：8346

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20163602780384);WOS:【SCI-EXPANDED(收录号:WOS:000383932900018)，CCR-EXPANDED(收录号:WOS:000383932900018)】；

基金：We are grateful for the financial support from the National Natural Science Foundation of China (21102043), Science and Technology Commission of Shanghai Municipality (15ZR1409200), and the Fundamental Research Funds for the Central Universities.

语种：英文

摘要：An efficient enantioselective synthesis of spiro[indoline-3,4'-pyrano[2,3-c]pyrazole] derivatives by a cascade reaction between pyrazolones and isatylidene malononitriles is described. With only 1 mol% of (DHQD)(2)PYR, chiral spirooxindole derivatives have been produced in excellent yields (96-99%) with good-to-excellent enantioselectivities (up to 91% ee).