文献类型：期刊文献

英文题名：Enantioselective Michael addition of 3-aryloxindoles to a vinyl bisphosphonate ester catalyzed by a cinchona alkaloid derived thiourea catalyst

作者：Zhao, Mei-Xin[1,2];Dai, Tong-Lei[1,2];Liu, Ran[1,2];Wei, Deng-Ke[1,2];Zhou, Hao[1,2];Jia, Fei-Hu[1,2];Shi, Min[1,2,3]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

年份：2012

卷号：10

期号：39

起止页码：7970

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20132216372443);WOS:【SCI-EXPANDED(收录号:WOS:000308929500017)，CCR-EXPANDED(收录号:WOS:000308929500017)】；

基金：We are grateful to the financial support from the National Natural Science Foundation of China (20772030, 21072056), the Fundamental Research Funds for the Central Universities, Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry.

语种：英文

外文关键词：Catalysis - Addition reactions - Catalysts - Enantioselectivity - Thioureas

摘要：A highly enantioselective Michael addition of 3-aryloxindole to vinyl bisphosphonate ester catalyzed by a cinchonidine derived thiourea catalyst has been investigated. The corresponding adducts, containing a chiral quaternary carbon center and geminal bisphosphonate ester fragment at the 3-position of the oxindole, were obtained in moderate to good yields (65-92%) and moderate to good enantioselectivities (up to 92% ee).