文献类型：期刊文献

英文题名：Palladium-catalyzed direct mono-aroylation of O-arytmethyl and aryl-substituted acetoxime ethers

作者：Shao, Ling-Yan[1];Xu, Zhi[1];Wang, Cun-Ying[2];Fu, Xiao-Pan[1];Chen, Miao-Miao[1];Liu, Hong-Wei[1];Ji, Ya-Fei[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Xuzhou Coll Ind Technol, Sch Chem Engn & Technol, Xuzhou 221006, Jiangsu, Peoples R China

年份：2018

卷号：16

期号：34

起止页码：6284

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000443172700014)，CCR-EXPANDED(收录号:WOS:000443172700014)】；

基金：We gratefully thank the National Natural Science Foundation of China (NSFC, project No. 21476074 and 21676088) for financial support.

语种：英文

摘要：An efficient palladium-catalyzed ortho-aroylation of O-arylmethyl and aryl-substituted acetoxime ethers has been developed; this method has high mono-site selectivity and does not require exogenous ligands. Under the direction of a simple exo-acetoxime auxiliary, a broad scope of masked arylmethyl alcohols and phenols as well as various aromatic aldehydes are compatible with this transformation, which probably follows a mechanistic pathway involving a six- or five-membered exo-cyclopalladated intermediate. The strategy can be expediently adopted to prepare synthetically valuable 1H-benzo[d][1,2]oxazines and benzo[d]isoxazoles. The directing group can be easily removed from the products to afford the functionalized diaryl ketones.